In connection with the establishment of the key role of androgens in the development of normal baldness and manifestations of the syndrome of hyperandrogenism, in the treatment of these diseases substances with antiandrogenic properties are used. Let's have a look at what an androgenetic alopecia is and how to deal with this unpleasant problem effectively.
Androgenetic alopecia is a genetically conditioned process characterized by a gradual progressive transition of pigmented thick hair into less pigmented subtle intermediates and eventually into vellus hair, followed by their complete loss. The main problem of androgenic alopecia in women and men is a reduction in hair growth due to the gradual contraction (miniaturization) of follicles on the scalp under the action of androgens.
More than 50% of men and the same number of women over 40 years old experience symptoms of androgenic hair loss. In 13% of the fairer sex, signs of baldness are already apparent in the reproductive age, but the maximum androgenetic alopecia in women reaches precisely after the onset of menopause. By the age of 50, this disease is more or less severe in most men, while in 25% of cases, baldness has an early onset, before reaching the age of 21.
Androgenic alopecia in women and men is one of the most common types of alopecia. According to the Western statistics, the signs of androgenic baldness are up to 33% of men and up to 65% of women. And among all types of alopecia this type of baldness is 95% for men, and for women 90%. In addition, this type of baldness is very difficult to treat, first, because it is associated with hormonal imbalance, and secondly, because hormonal disorders are often associated with a genetic predisposition.
If a man has been diagnosed androgenic alopecia quite simply because of the characteristic clinical signs, in women, a rapid diagnosis can be made only if along with progressive thinning and hair loss there are other signs - excessive body hair (hirsutism), seborrhea and acne. In other cases, microscopic examination of hair follicles and other diagnostic methods is necessary.
Symptoms of androgenic alopecia in men and women vary, but in general for both sexes there are a number of common symptoms:
• a gradual onset,
• increased hair loss,
• thinning of thick pigmented terminal hair shafts in the affected areas.
The final result is a complete loss of hair in the parietal region and on the vertex. Androgenic alopecia in men (the initial stage) is characterized by thinning and thinning of the hair cover over the upper part of the face, as well as raising the border of the forehead by changing the shape of the front part of the hair growth line. The process progresses towards the thinning crown, followed by fusion and the formation of a wide area of baldness with the preservation of the hair on the sides and in the back of the head (the shape of the horseshoe). Symptoms of androgenic alopecia in women include diffuse thinning, beginning in the parietal zone, with subsequent progression until complete loss of hair cover.
The main mechanism of hormonal alopecia is associated with the effect on the hair follicles of the male hormone testosterone, or rather its most active hypostasis - dihydrotestosterone (DHT). In this case, hair loss is caused either by an increased content of DHT, or by increased sensitivity to it of hair follicles of certain areas of the scalp.
Particularly sensitive to DHT follicles are found in men on the frontal, parietal and occipital part of the head, which determines the pattern of male pattern baldness. Women on the frontal part of the head are sensitive to DHT receptors 40% less than men, which saves them from bald patches, and on the occipital part they are almost none.
Propecia is a drug inferior in popularity to men only to Viagra. This extremely effective remedy is designed to treat male pattern baldness, that is, alopecia androgenic form. Propecia is a one-of-a-kind drug approved by the US Food and Drug Administration. Propecia is a synthetic 4-azosteroid, a specific inhibitor of 5a-reductase type II; when administered orally reduces the level of DTS, without changing the levels of testosterone, cortisol, prolactin, thyroxine, estradiol and globulin, binding sex hormones.
For the treatment of common baldness in men, Propecia is recommended in a dose of 1 mg per day. Propecia prevents the progression of alopecia and promotes the growth of new hair. The drug is intended for long-term (12-24 months) use. The therapeutic effect is noticeable after 3-6 months of total treatment, but a significant clinical improvement is observed by the end of the first year of therapy in 48% of patients and by the end of the second year - in 80%. The drug is indicated for the treatment of androgenic baldness only in men: it is most effective at initial and moderately expressed alopecia (I-III types according to J. Hamilton); does not affect the growth of hair in the region of the bitemporal bald patches.
For several years, clinical studies of the drug Propecia have been conducted. These studies, as well as the fact that millions of men around the world successfully and effectively use Propecia tablets, prove that this drug is not only effective against baldness, but also safe for health. The active component of the preparation Propecia - finasteride for a long time stimulates hair growth and resists prolapse. This substance has a side effect - its use can adversely affect the sexual function of men, but this effect was observed only in 5% of patients, and with the end of the treatment process, it completely disappeared.
As already noted, the main active substance of Propecia is finasteride, which became widespread in 1992, when it was used in medical practice for the treatment of prostatic hyperplasia. Men who received the treatment of baldness finasteride, began to note the increase in hair growth in the forehead and head of the head. What is the effect of Propecia on the body? The point is that the excess dihydrotestosterone - one of the male hormones needed at the stage of development and maturation of the male body, with age leads to alopecia.
The accumulation of DHT in the hair follicles leads to their dystrophy and gradual narrowing, which causes the hair growth to stop and further their death. For the formation of dihydrotestosterone, five-alpha-reductase is necessary, and the active substance Propecia, being an inhibitor of this enzyme, prevents the formation of DHT in the hair follicles and allows successfully to combat the cause of baldness. Decrease in DHT level best affects the structure and condition of the hair, they acquire a healthy appearance, the ability to grow and replace the fallen hairs is restored.
This preparation is produced in the form of tablets, each of which contains 1 mg of the active ingredient finasteride. As a rule, Propecia tablets are octagonal in shape, covered with a pale brown coating. However, in principle, they may have a slightly different design, as they are produced in different factories in different countries. As for the treatment of female androgenetic alopecia, Propecia could be just as effective, but its main active ingredient, Finasteride, increases the likelihood of congenital fetal anomalies in pregnant women. This circumstance forced the development company Merck & Co., Inc. to categorically prohibit the use of Propecia in women of childbearing age.
Using Propecia gives excellent results, and hair growth is restored both on the crown and in the area of the bald areas on the forehead, which are usually treated with difficulty. Although, different results are obtained for different patients, more than 60% of men instead of hair fall out a large number of new ones, while the rest of the hair has recovered completely or even increased in comparison with the normal level.
Clinical studies confirm the high efficacy of Propecia. By their results, just under 90% of the subjects noticed that their hair stopped falling out. A year later, half of the patients resumed their hair growth. And after 18 months, the percentage of men whose hair acquired a "second life" rose to 66%. Finasteride gives tremendous results, restores hair bulbs on the crown, and also eliminates the bald patches in the forehead, ideally coping with the so-called male pattern of alopecia. Before the advent of Propecia, there was an opinion that these areas of the head are the least treatable, since it is there that the hair follicles are sensitive to the effects of the male sex hormone. This drug with proven effectiveness returns the hair to the strong sex.
Instead of falling out, absolutely normal healthy hair grows, and not some fluff. In the most severe cases of baldness, patients using Propecia, at least, retain the amount of hair that they had at the beginning of the course of treatment. In any case, the balding man who uses Propecia, has a high chance of regaining hair.
The regular reception of finasteride leads to the renewal of bulbs that produce cannula hair, and stimulates the growth of full-fledged real hair. It is quite natural that the final results can be different depending on the individual characteristics of the human body. Until now, it was believed that to cure androgenetic alopecia with one hundred percent effectiveness is possible only in women. The effectiveness of drug therapy for men is usually determined by stages of the disease according to the Norwood scale from I to VII, and it is recommended to begin treatment of baldness as early as possible in order to achieve greater effect.
As research has shown, even in neglected cases, the use of Propecia allows, if not to return the lost hair completely, then at least completely prevent further baldness, and keep the remaining amount of hair. If you show patience and perseverance, repeat treatment courses, then a year later, or a little more, you can leave problems with alopecia in the past, and admire a much more lush and thick hairstyle.